1. not graphics or system related since it happens on multiple machines with different versions of OS/CPU/Graphics cards.
FYI, I play on a 3000+Amd with XP pro and 1 GB mem and Geforce6800GT and a Core2Duo1600Ghz XP home with dedicated Geforce Go and 1GB ram
2. Interaction bug.
d. Weps and skills: Any targetted offensive melee weapon required spell, e.g. Holly Roller, Butcher, Soul Rend (migh
g. detailed description/reproduce

When using any targetting offensive melee spells, esp. soul rend, if the targetted monster moves/dies, or if the attack misses, the player is left with a red X in place of a cursor which will not always turn green or allow attack when mouse over an enemy. After a few seconds of holding LMB spell times out and can attack again normal, or can interrupt spell with RMB for normal attack.

This bug only applies to hotkey spells, not mouse bound spells. Please PM if you have further questions.